Objective: Cardiopulmonary bypass (CPB) induces an inflammatory response, which can cause loss of alkaline phosphatase (AP) consumed in the process of extracellular nucleotides dephosphorylating disadvantage in this proinflammatory state. It has been reported that the rate of postoperative low AP correlated with increased support needs post surgery and organ dysfunction after pediatric cardiac surgery. However, little is known about the development of perioperative and clinical relevance of depletion AP in adults undergoing CPB.

Methods: A total of 183 patients with left ventricular ejection fraction ≤50% preoperatively underwent mitral valve surgery ± concurrent procedure related in the Department of Cardiac Surgery, Medical University of Vienna, between 2013 and 2016 were included in this retrospective analysis. AP serum measurements at baseline and at days 1-15 post surgery were collected. AP absolute and relative reduction in postoperative day 1 of baseline parameters correlated with perioperative and postoperative early. Receiver operating characteristics used to determine predictors fit and cut-off for postoperative outcome variables.

Results: The operating characteristics Receiver showed a decrease of> 50% of the base AP to predict in-hospital mortality [area under the curve (AUC) 0.807], prolonged intensive care unit stay (> 72 hours, AUC 0.707), mechanical ventilation prolonged (> 24 hours, AUC 0.712) and need for dialysis-related operasi- (AUC 0.736). Patients with perioperative decrease in circulating AP to levels below 50% of the base has significantly decreased survival. Patients with high loss of perioperative AP AP preoperative levels of higher (P <0.001), longer duration of CPB (P <0.001) and a higher incidence of lung artificial support (P <0.001).

Conclusion: Increased perioperative AP loss associated with early adverse outcomes. prospective trial is needed to determine whether this effect can be neutralized by AP perioperative supplementation.

Difference Serum Alkaline Phosphatase Levels in Infants with spontaneous intestinal perforation compared Necrotizing enterocolitis with perforation

Introduction: Data laboratory markers spontaneous intestinal perforation (SIP) and necrotizing enterocolitis (NEC) remains sparse.
Objective: To compare serum levels of alkaline phosphatase in infants with intestinal perforation secondary to SIP vs NEC surgery, and then investigate the possible role of serum alkaline phosphatase to distinguish infants with this condition.

Methods: A retrospective case-control study of infants admitted with bowel perforation from 2005 to 2015. Demographics and Data prenatal, postnatal exposure, and clinical, laboratory, and radiographic findings were drawn from inpatient medical records and analyzed using regression analysis.

p38
MBS8533658-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38
MBS8533658-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38
MBS8533658-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

P38 mAb
MBS435304-005mL	MyBiosource	0.05mL	EUR 415

P38 mAb
MBS435304-01mL	MyBiosource	0.1mL	EUR 660

P38 mAb
MBS435304-5x01mL	MyBiosource	5x0.1mL	EUR 2655

p38 MAPK
E8ET1702-65	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Mxi2, p38
MBS603655-01mg	MyBiosource	0.1mg	EUR 820

Mxi2, p38
MBS603655-5x01mg	MyBiosource	5x0.1mg	EUR 3530

p38 MAPK
MBS8534372-01mL	MyBiosource	0.1mL	EUR 345

p38 MAPK
MBS8534372-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 MAPK
MBS8534372-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 MAPK
MBS8534372-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 MAPK
MBS8534372-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 protein
E20-80078	EnoGene	20ug	EUR 275
Description: N/A

p38 protein
E20-80079	EnoGene	20ug	EUR 275
Description: N/A

p38 protein
MBS8526800-002mg	MyBiosource	0.02mg	EUR 345

p38 protein
MBS8526800-5x002mg	MyBiosource	5x0.02mg	EUR 1410

p38 protein
MBS8526801-002mg	MyBiosource	0.02mg	EUR 345

p38 protein
MBS8526801-5x002mg	MyBiosource	5x0.02mg	EUR 1410

p38 Antibody
20-abx007541	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 antibody
70R-51505	Fitzgerald	100 ul	EUR 242
Description: Purified Polyclonal p38 antibody

p38 antibody
70R-51506	Fitzgerald	100 ul	EUR 286
Description: Purified Polyclonal p38 antibody

p38 Antibody
35478	SAB	100ul	EUR 479

p38 Antibody
35478-100ul	SAB	100ul	EUR 468

p38 Antibody
20-abx133223	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 Antibody
48644	SAB	100ul	EUR 499

p38 Antibody
48644-100ul	SAB	100ul	EUR 399.6

p38 Antibody
48644-50ul	SAB	50ul	EUR 286.8

p38 Antibody
20-abx141038	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

p38 Antibody
B7178-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B7178-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0798-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0798-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0799-100ul	Assay Biotech	100μl	EUR 217
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
B0799-50ul	Assay Biotech	50μl	EUR 143.5
Description: p38 Rabbit Polyclonal Antibody

p38 Antibody
abx236076-100g	Abbexa	100 µg	EUR 350

p38 Antibody
abx236076-100ug	Abbexa	100 ug	EUR 577.2

p38 Antibody
E38PA4721	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA5060	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA5094	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA7126	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
E38PA3186	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Antibody
MBS5316121-01mL	MyBiosource	0.1mL	EUR 460

p38 Antibody
MBS5316121-5x01mL	MyBiosource	5x0.1mL	EUR 1920

p38 Antibody
MBS5316122-01mL	MyBiosource	0.1mL	EUR 535

p38 Antibody
MBS5316122-5x01mL	MyBiosource	5x0.1mL	EUR 2270

p38 Antibody
MBS8002013-0025mL	MyBiosource	0.025mL	EUR 315

p38 Antibody
MBS8002013-5x0025mL	MyBiosource	5x0.025mL	EUR 890

p38 Antibody
MBS805089-01mL	MyBiosource	0.1mL	EUR 425

p38 Antibody
MBS805089-5x01mL	MyBiosource	5x0.1mL	EUR 1350

p38 Antibody
MBS806203-0025mL	MyBiosource	0.025mL	EUR 320

p38 Antibody
MBS8581787-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8581787-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8581787-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8581787-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8581787-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8584173-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8584173-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8584173-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8584173-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8584173-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582665-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582665-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582665-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582665-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582665-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582905-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582905-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582905-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582905-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582905-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS8582923-01mL	MyBiosource	0.1mL	EUR 305

p38 Antibody
MBS8582923-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 465

p38 Antibody
MBS8582923-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 465

p38 Antibody
MBS8582923-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 465

p38 Antibody
MBS8582923-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 465

p38 Antibody
MBS9508977-005mL	MyBiosource	0.05mL	EUR 285

p38 Antibody
MBS9508977-01mL	MyBiosource	0.1mL	EUR 385

p38 Antibody
MBS9508977-5x01mL	MyBiosource	5x0.1mL	EUR 1590

p38 Antibody
MBS9409774-01mL	MyBiosource	0.1mL	EUR 420

p38 Antibody
MBS9409774-5x01mL	MyBiosource	5x0.1mL	EUR 1740

p38 Antibody
MBS9435492-005mL	MyBiosource	0.05mL	EUR 325

p38 Antibody
MBS9435492-01mL	MyBiosource	0.1mL	EUR 435

p38 Antibody
MBS9435492-5x01mL	MyBiosource	5x0.1mL	EUR 1810

p38 Antibody
SPC-172D	Stressmarq	0.1ml	EUR 161
Description: Rabbit Anti-Human p38 Polyclonal

p38 Antibody
SPC-172S	Stressmarq	0.012ml	Ask for price
Description: Rabbit Anti-Human p38 Polyclonal

p38 Substrate
MBS517838-1mg	MyBiosource	1mg	EUR 205

p38 Substrate
MBS517838-5x1mg	MyBiosource	5x1mg	EUR 675

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS657552-10Blots	MyBiosource	10Blots	EUR 430

MAP Kinase p38, Control Cell Extracts (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS657552-5x10Blots	MyBiosource	5x10Blots	EUR 1785

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS633592-01mL	MyBiosource	0.1mL	EUR 695

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS633592-5x01mL	MyBiosource	5x0.1mL	EUR 2985

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS632290-02mL	MyBiosource	0.2mL	EUR 660

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS632290-5x02mL	MyBiosource	5x0.2mL	EUR 2810

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-02mL	MyBiosource	0.2mL	EUR 650

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-06mL	MyBiosource	0.6mL	EUR 1175

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS630803-5x06mL	MyBiosource	5x0.6mL	EUR 5140

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS627818-10Blots	MyBiosource	10Blots	EUR 875

MAP Kinase p38, phosphorylated (Thr180, Tyr182) (Mitogen Activated Protein Kinase p38, MAPK p38)
MBS627818-5x10Blots	MyBiosource	5x10Blots	EUR 3785

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor
E1B1863	EnoGene	1mg	EUR 85

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor
MBS8579825-1mg	MyBiosource	1mg	EUR 180

SB-203580 p38 MAPK (p38 MAP kinase) Inhibitor
MBS8579825-5x1mg	MyBiosource	5x1mg	EUR 660

p38 (411-425) M.leprae
MBS8246858-10mg	MyBiosource	10mg	EUR 675

p38 (411-425) M.leprae
MBS8246858-1mg	MyBiosource	1mg	EUR 255

p38 (411-425) M.leprae
MBS8246858-5mg	MyBiosource	5mg	EUR 480

p38 (411-425) M.leprae
MBS8246858-5x10mg	MyBiosource	5x10mg	EUR 2955

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)
MBS631660-04mL	MyBiosource	0.4mL	EUR 670

MAP Kinase p38, phosphorylated (Thr180, Ty182) (Mitogen Activated Protein Kinase p38, MAPK p38) (Agarose)
MBS631660-5x04mL	MyBiosource	5x0.4mL	EUR 2870

Anti - p38-a
MBS684252-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-a
MBS684252-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-a
MBS684252-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-a
MBS684252-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-b
MBS684253-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-b
MBS684253-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-b
MBS684253-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-b
MBS684253-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-g
MBS684254-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-g
MBS684254-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-g
MBS684254-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-g
MBS684254-5x01mL	MyBiosource	5x0.1mL	EUR 2925

Anti - p38-d
MBS684255-002mL	MyBiosource	0.02mL	EUR 270

Anti - p38-d
MBS684255-005mL	MyBiosource	0.05mL	EUR 485

Anti - p38-d
MBS684255-01mL	MyBiosource	0.1mL	EUR 720

Anti - p38-d
MBS684255-5x01mL	MyBiosource	5x0.1mL	EUR 2925

p38 Mouse mAb
E2220879	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Mouse mAb
E2222580	EnoGene	100ul	EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

p38 Mouse mAb
MBS8539086-01mL	MyBiosource	0.1mL	EUR 305

p38 Mouse mAb
MBS8539086-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

p38 Mouse mAb
MBS8539086-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

p38 Rabbit pAb
E2340697	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb
E2380881	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

p38 Rabbit pAb
E2381051	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Results: Of the 114 infants included outborn, 48 babies have SIP (cases) and 66 have NEC (control). Upon entry of the hospital refers, serum alkaline phosphatase levels were significantly higher in infants with SIP, ie, the median value of versus236 782 U / L in patients with NEC (p <0.0001), with an adjusted odds ratio (OR) of 4.3 (p <0.05) when the level is> 500 U / L in a multivariate regression model. Infants with gestational age SIP has significantly younger, presented earlier in life, especially with pneumoperitoneum, and have a greater exposure to steroids and indomethacin compared infants with NEC. alkaline phosphatase levels decreased rapidly in infants with the following SIP entry.

Conclusion: A temporary increase in serum alkaline phosphatase levels were independently associated with SIP when compared to the NEC. Studies confirm the role of alkaline phosphatase in the diagnosis of the necessary SIP and has clinical implications and potential prognostic significance.